More than a FAD: The In Vivo Effects of Disease-Linked Presenilin-1 Mutations

نویسندگان

  • Kathleen R. Zahs
  • Karen H. Ashe
چکیده

Mutations in presenilins are linked to familial autosomal dominant Alzheimer's disease. In this issue of Neuron, Xia et al. (2015) show that a disease-linked mutation leads to loss of γ-secretase function, cognitive decline, and neurodegeneration when knocked into the mouse genome.

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عنوان ژورنال:
  • Neuron

دوره 85  شماره 

صفحات  -

تاریخ انتشار 2015